Source:http://www.reactome.org/biopax/48887BiochemicalReaction3253
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Authored: Orlic-Milacic, M, 2012-04-04,
Edited: Jassal, B, 2012-04-10,
Reviewed: Huang, Tao, 2012-05-14,
STRAP (serine-threonine kinase receptor-associated protein) is able to bind the unphosphorylated TGF-beta receptor complex. In addition, in in vitro studies, STRAP was shown to interact individually with both TGFBR1 and TGFBR2 in the absence of TGF-beta stimulation (Datta et al. 1998). This was inferred from experiments using recombinant mouse Strap with recombinant human TGF-beta receptors.
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STRAP binds unphosphorylated TGF-beta receptor complex
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