Source:http://www.reactome.org/biopax/48887BiochemicalReaction3251
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Authored: Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02,
Edited: Jassal, B, 2006-02-10 14:02:35,
Edited: Jassal, B, 2012-04-10,
I-SMADs (SMAD6 and SMAD7) reside in the nucleus presumably to be sequestered from the TGF-beta receptor complex and thus avoid inappropriate silencing of the signaling pathway. Upon activation of the signaling pathway, I-SMADs exit the nucleus and are recruited to the signaling TGF-beta receptor complex. I-SMADs directly bind to the so-called L45 loop of the type I receptor, the site of binding of R-SMADs. Thus, I-SMADs competitively inhibit the activation/phosphorylation of R-SMADs.,
Reviewed: Heldin, CH, 2006-04-18 14:26:12,
Reviewed: Huang, Tao, 2012-05-14
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I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
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