Source:http://www.reactome.org/biopax/48887BiochemicalReaction3248
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Authored: Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02,
Edited: Jassal, B, 2006-01-18 10:19:52,
Reviewed: Heldin, CH, 2006-04-18 14:26:12,
Reviewed: Huang, Tao, 2012-05-14,
The activated TGF-beta receptor complex is internalized by clathrin-mediated endocytosis into early endosomes. SARA resides in the membrane of early endosomes. Crystallographic studies suggest that dimeric SARA in the early endosome coordinates two R-SMAD molecules (SMAD2 and/or SMAD3) per one receptor complex.
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An anchoring protein, SARA, recruits SMAD2/3
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