Source:http://www.reactome.org/biopax/48887BiochemicalReaction3174
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Authored: Orlic-Milacic, M, 2011-11-04,
Edited: Matthews, L, 2011-11-07,
Reviewed: Neckers, LM, 2011-11-11,
Reviewed: Xu, W, 2011-11-11,
p85 subunit of PI3K (PIK3R1) directly binds to any of the two phosphorylated ERBB4 CYT1 isoforms in complex with ERBB2 through interaction with a phosphorylated tyrosine residue in the C-tail of ERBB4 CYT1 (Y1056 in ERBB4 JM-A CYT1; Y1046 in ERBB4 JM-B CYT1).
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Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB2:p-ERBB4 CYT-1 heterodimers
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