Source:http://www.reactome.org/biopax/48887BiochemicalReaction3168
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Authored: Orlic-Milacic, M, 2011-11-04,
Edited: Matthews, L, 2011-11-07,
Reviewed: Neckers, LM, 2011-11-11,
Reviewed: Xu, W, 2011-11-11,
SOS1 bound to GRB2 in complex with phosphorylated ERBB2:EGFR heterodimer catalyzes guanyl-nucleotide exchange on RAS, leading to activation of the MAP kinase cascade.
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RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
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