Source:http://www.reactome.org/biopax/48887BiochemicalReaction3157
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Authored: Garapati, P V, 2011-07-11,
Edited: Garapati, P V, 2011-07-11,
Reviewed: Rönnstrand, L, 2011-08-22,
Tyrosine phosphatase PTPRO associates constitutively with c-Kit independently of SCF stimulation. PTPRO undergoes phosphorylation upon SCF stimulation. The PTPRO binding site on c-Kit and the molecular mechanism by which c-Kit signaling is regulated by PTPRO have not been determined.
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PTP-RO interacts with p-c-Kit complex
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