Source:http://www.reactome.org/biopax/48887BiochemicalReaction3150
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Authored: Garapati, P V, 2011-07-11,
Edited: Garapati, P V, 2011-07-11,
Reviewed: Rönnstrand, L, 2011-08-22,
The protein tyrosine phosphatase SHP-1 negatively regulates KIT signaling through binding to phosphorylated Y570. It is unclear whether SHP1 directly dephosphorylates KIT or elicits dephosphorylation of the receptor indirectly by dephosphorylating and inhibiting cytosolic PTKs that act on KIT. SHP-1 may also compete with and displace SFKs or other proteins that dock to phosphorylated Y570 (Kozlowski et al, 1998).
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Interaction of SHP1 and KIT
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