Source:http://www.reactome.org/biopax/48887BiochemicalReaction3149
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Authored: Garapati, P V, 2011-07-11,
Edited: Garapati, P V, 2011-07-11,
Protein kinase C (PKC) alpha phosphorylates and regulates the activity of several receptor tyrosine kinases including KIT. PKC alpha is involved in a negative feedback loop regulating SCF induced proliferation by phosphorylating and inhibiting the kinase activity of KIT (Blume-Jensen et al. 1994, 1995). PKC alpha phosphorylates KIT on S741 and S746 of the kinase insert (Blume-Jensen et al. 1995). This serine phosphorylation inhibits KIT kinase activity and reduces the capacity of multiple SH2 containing signaling components to associate with KIT (Linnekin 1999).,
Reviewed: Rönnstrand, L, 2011-08-22
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PKC alpha interacts with and phosphorylates KIT
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2.7.11
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