Linked Life Data

48887BiochemicalReaction3140

Source:http://www.reactome.org/biopax/48887BiochemicalReaction3140

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Authored: Garapati, P V, 2011-07-11, Edited: Garapati, P V, 2011-07-11, Once recruited to the membrane in response to c-Kit stimulation, Son of sevenless (SOS1) activates the small GTPase protein Ras. SOS1 is a dual specificity guanine nucleotide exchange factor (GEF) that regulates both Ras and Rho family GTPases. SOS1 activates Ras by binding which induces a conformational change that causes the exchange of GDP with GTP. Ras proteins are membrane-bound GTPases that regulate crucial cellular processes such as growth, proliferation and differentiation. Active Ras-GTP stimulates multiple effector proteins such as Raf-1, which induce a variety of cellular responses, including initiation of mitogen activated protein kinase (MAPK) cascade signaling., Reviewed: Rönnstrand, L, 2011-08-22
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Activation of RAS by p-KIT bound SOS1
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