Source:http://www.reactome.org/biopax/48887BiochemicalReaction3137
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Authored: Garapati, P V, 2011-07-11,
Edited: Garapati, P V, 2011-07-11,
Reviewed: Rönnstrand, L, 2011-08-22,
The scaffolding adapter GAB2 plays a role in KIT dependent PI3K/AKT activation. GAB2 interacts with KIT indirectly via the adapter protein GRB2 which is bound to KIT on phosphorylated Y703 and Y936 (Sun et al. 2008, Yu et al. 2006).
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Indirect recruitment of GAB2 to p-KIT
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