Linked Life Data

48887BiochemicalReaction3128

Source:http://www.reactome.org/biopax/48887BiochemicalReaction3128

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
biopax3:comment
Authored: Garapati, P V, 2011-07-11, Edited: Garapati, P V, 2011-07-11, PI3 kinases catalyze the production of phosphatidylinositol-3, 4, 5-triphosphate (PIP3) by phosphorylating phosphatidylinositol-4, 5-bisphosphate (PIP2). PIP3 bound to the inner lipid bilayer of the plasma membrane promotes the recruitment and activation of AKT. Active AKT subsequently phosphorylates the pro-apoptotic factor Bad at Ser136 which leads to it binding 14-3-3 protein and sequestering from the anti-apoptotic molecules Bcl-XL therby reducing antiapoptotic events and promoting cell survival. The alternative route for c-Kit mediated survival is through AKT-mediated phosphorylation and incativation of the forkhead transcription factor (FoxO3a) (Engstrom et al, 2003; Lennartson et al , 2005)., Reviewed: Rönnstrand, L, 2011-08-22
biopax3:xref
biopax3:dataSource
biopax3:displayName
Synthesis of PIP3 from PIP2 by PI3K
biopax3:left
biopax3:right