Source:http://www.reactome.org/biopax/48887BiochemicalReaction3125
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Authored: Garapati, P V, 2011-07-11,
Binding of the SCF dimer to KIT rapidly triggers KIT dimerization and autophosphorylation. It is thought that one SCF dimer binds simultaneously to two KIT monomers. The fourth Ig-like domain of KIT contains the dimerisation site; deletion of this domain completely abolishes KIT dimerisation and subsequent downstream signaling (Edling et al. 2007, Blechman et al. 1995). KIT dimerization is a crucial initial step in the SCF signal transduction process.,
Edited: Garapati, P V, 2011-07-11,
Reviewed: Rönnstrand, L, 2011-08-22
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| biopax3:xref |
http://identifiers.org/pubmed/17255936,
http://identifiers.org/pubmed/17350321,
http://identifiers.org/pubmed/17662946,
http://identifiers.org/pubmed/7529140,
http://identifiers.org/pubmed/8636116,
http://identifiers.org/pubmed/9045650,
http://identifiers.org/pubmed/9446650,
urn:biopax:UnificationXref:REACTOME DATABASE ID_205231,
urn:biopax:UnificationXref:REACTOME_REACT_111210_1
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Dimerization of KIT upon SCF binding
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