Source:http://www.reactome.org/biopax/48887BiochemicalReaction3113
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Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27,
Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27,
Reviewed: Heldin, CH, 2008-11-23 19:29:34,
The presence of both SH2 and SH3 domains in Crk proteins is of crucial importance for their function as adaptor molecules. Crk forms complex with Cas, an SH3 domain-containing docking protein which has been shown to be phosphorylated after PDGF-stimulation of cells, and C3G, a nucleotide exchange protein which has been linked to the activation of JNK.
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p130Cas and C3G bind PDGFR bound Crk
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