Source:http://www.reactome.org/biopax/48887BiochemicalReaction3098
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Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27,
Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27,
Receptor dimerisation is key event in PDGF receptor activation. The intracellular parts of the receptors are juxtaposed which allows trans-phosphorylation between the two receptors in the complex.<br>The autophosphorylation site Y857 located inside the kinase domain of beta-receptor is important for activation of the kinase. This tyrosine is conserved in the alpha-receptor (Y849 ) and in almost all other tyrosine kinase receptors. The other known autophosphorylation sites are localized outside the kinase domains of the alpha- and beta- receptors ; 11 out of 15 tyrosine residues in the intracellular, non-catalytic part of the beta-receptor are autophosphorylation sites,
Reviewed: Heldin, CH, 2008-11-23 19:29:34
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Autophosphorylation of PDGF alpha receptors
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2.7.10
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