Source:http://www.reactome.org/biopax/48887BiochemicalReaction3092
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After dimerization of the PDGF-A and PDGF-B chains in the ER of producing cells, the dimers are proteolytically cleaved in the trans-Golgi network during protein maturation and secretion. The dibasic-specific proprotein convertase, furin, or related convertases are involved in the conversion of proPDGF forms to active PDGF forms.,
Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27,
Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27,
Reviewed: Heldin, CH, 2008-11-23 19:29:34
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Processing of classical PDGFs
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| biopax3:eCNumber |
3.4.21
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