Source:http://www.reactome.org/biopax/48887BiochemicalReaction3084
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Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07,
Reviewed: Greene, LA, 2007-11-08 15:39:37,
Several guanine exchange factors (GEFs) for the Rho family of GTPases contain PH domains that bind to PIP3. RhoA protein activation is a mechanism whereby PI3K acts independently of AKT.
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PIP3 binds to RhoA and activates it
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