Source:http://www.reactome.org/biopax/48887BiochemicalReaction3065
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Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07,
Edited: Jassal, B, 2006-10-10 09:20:18,
Once activated by RIT or RIN, B-RAF activates, through MEK, the p38 MAP kinase. Whereas RIN appears to activate p38 (specifically the p38-alpha isoform) but not the ERKs, RIN was described to activate ERK1/ ERK2 as well, although to a much lower extent than p38. RIN signaling gives rise to sustained activation of p38 MAP kinase.,
Reviewed: Greene, LA, 2007-11-08 15:39:37
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RIT/RIN-GTP binds B-RAF
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