Source:http://www.reactome.org/biopax/48887BiochemicalReaction3032
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Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07,
Edited: Jassal, B, 2008-05-20 12:26:36,
IkB is an inhibitory protein that sequesters NF-kB in the cytoplasm, by masking a nuclear localization signal, located just at the C-terminal end in each of the NF-kB subunits. A key event in NF-kB activation involves phosphorylation of IkB by an IkB kinase (IKK). NGF stimulates the activity of the IkB kinase IKK-beta, and, possibly, IKK-alpha as well. Once IkB is phosphorylated, the IkB:NF-kB complex dissociates.,
Reviewed: Chao, MV, 2008-05-28 09:46:01,
Reviewed: Friedman, WJ, 2008-05-20 12:23:46
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IKKbeta phosphorylates IkB causing NF-kB to dissociate
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2.7.11
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