Source:http://www.reactome.org/biopax/48887BiochemicalReaction3031
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| biopax3:comment |
Atypical PKC isoforms phosphorylate the beta subunit of the IKK complex (on Serines 177 and 181) thereby serving as an IKK kinase. TRAF6 and p62 as well appear to have a role in IKK activation. TRAF6 mediates the assembly of K63-linked poly-Ub chains required for IKK activation. The ubiquitin binding property of p62 may also be relevant in regulating IKK activation.,
Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07,
Edited: Jassal, B, 2008-05-20 12:26:36,
Reviewed: Chao, MV, 2008-05-28 09:46:01,
Reviewed: Friedman, WJ, 2008-05-20 12:23:46
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| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
IKKbeta is activated
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| biopax3:eCNumber |
2.7.11
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