Source:http://www.reactome.org/biopax/48887BiochemicalReaction2982
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Authored: Charalambous, M, 2005-01-07 11:17:43,
Edited: Schmidt, EE, 0000-00-00 00:00:00,
Inactive p21ras-GDP is found anchored to the plasma membrane by a farnesyl residue.<br>Insulin stimulation results in phosphorylation of IRS1/2 on tyrosine residues (Y). GRB2 binds the phosphotyrosine residues of IRS via its SH2 domain. As IRS is phosphorylated by the insulin receptor near to the plasma membrane, the SOS-GRB2:IRS interaction brings the SOS enzyme into close proximity to p21ras.
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GRB2:SOS binds IRS-P
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