Source:http://www.reactome.org/biopax/48887BiochemicalReaction2945
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Authored: Jassal, B, 2004-12-15 13:08:03,
Edited: D'Eustachio, P, 2012-02-06,
Edited: Orlic-Milacic, M, 2012-02-10,
NEXT1 fragment of NOTCH1 is further cleaved at S3 by the presenilin-1 (PSEN1) containing gamma-secretase complex, which releases the intracellular domain NICD1 into the cytosol (Schroeter et al. 1998, De Strooper et al. 1999, Huppert et al. 2000, Fortini et al. 2002). PIN1, a prolyl isomerase, was recently found to bind phosphorylated Ser/Thr-Pro motifs in the cytoplasmic domain of NOTCH1 and potentiate NEXT1 cleavage by gamma-secretase. This generates a positive loop in NOTCH1 signaling since PIN1 is a transcriptional target of NICD1 (Rustighi et al. 2009).,
Reviewed: Haw, R, 2012-02-06,
Reviewed: Joutel, A, 2004-12-15
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| biopax3:xref |
http://identifiers.org/pubmed/10206645,
http://identifiers.org/pubmed/10879540,
http://identifiers.org/pubmed/12209127,
http://identifiers.org/pubmed/19151708,
http://identifiers.org/pubmed/9620803,
urn:biopax:UnificationXref:REACTOME DATABASE ID_157353,
urn:biopax:UnificationXref:REACTOME_REACT_1784_4
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NEXT1 is cleaved to produce NICD1
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3.4.23
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