Source:http://www.reactome.org/biopax/48887BiochemicalReaction2926
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Authored: Jupe, S, 2010-10-14,
Edited: Jupe, S, 2011-06-10,
Reviewed: Herington, AC, 2011-06-13,
Reviewed: Waters, MJ, 2011-06-23,
SHP1 binds GH-activated JAK2 and controls the duration of GH-dependent JAK2 phosphorylation in the liver, consequently hepatic GH signaling is prolonged in mice lacking SHP1 (Hackett et al. 1999).
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SHP1 (PTPN6) binds JAK2 in the receptor complex
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