Source:http://www.reactome.org/biopax/48887BiochemicalReaction2923
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Authored: Jupe, S, 2010-10-14,
Edited: Jupe, S, 2011-06-10,
PTP1B has been shown to associate with GH-dependent phosphorylated GHR and induce its dephosphorylation (Pasquali et al. 2003). It can also dephosphorylate JAK2 (Gu et al. 2003). Both have the effect of reducing JAK signaling.,
Reviewed: Herington, AC, 2011-06-13,
Reviewed: Waters, MJ, 2011-06-23
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PTP1B binds the GH receptor complex
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