Source:http://www.reactome.org/biopax/48887BiochemicalReaction2907
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Authored: Jupe, S, 2010-10-14,
Edited: Jupe, S, 2011-06-10,
JAKs bind to the box1 motif (residues 297-305) of the Growth Hormone Receptor (GHR) (Argetsinger et al. 1993), a proline-rich region just inside the cell membrane. Binding is mediated largely by the JAK N-terminal FERM domain (Frank et al. 1995, He et al. 2003). JAK 2 binding enhances the stability of GHR (He et al. 2005).,
Reviewed: Herington, AC, 2011-06-13,
Reviewed: Waters, MJ, 2011-06-23
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Growth hormone receptor binds JAK2
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