Source:http://www.reactome.org/biopax/48887BiochemicalReaction2861
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Authored: Ray, KP, 2010-05-17,
Edited: Jupe, S, 2010-08-06,
JAK2 phosphorylates STAT5; phosphorylated STAT5 dimerizes and translocates to the nucleus (Darnell et al., 1994), binds DNA and activates target genes including c-fos, pim-1, oncostatin M, and Id-1 (Mui et al. 1996). STAT5 activation is believed to be the primary signaling mechanism for Bc (Ihle, 2001).,
Reviewed: Hercus, TR, 2010-09-06,
Reviewed: Lopez, AF, 2010-09-06
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Activation of STAT5a/b by JAK2
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2.7.10
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