Source:http://www.reactome.org/biopax/48887BiochemicalReaction2851
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Authored: Ray, KP, 2010-05-17,
Edited: Jupe, S, 2010-08-06,
Reviewed: Hercus, TR, 2010-09-06,
Reviewed: Lopez, AF, 2010-09-06,
The GM-CSF receptor alpha subunit has a single transmembrane domain, a glycosylated extracellular domain and a short (54 amino acids) cytoplasmic tail, containing no tyrosine kinase domain (Gearing et al. 1989). It binds GM-CSF with a relatively low affinity, and is not capable of signaling. The cytoplasmic domain of the alpha chain appears to be critical for GM-CSF signaling (Matsuguchi et al. 1997).
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GM-CSF receptor alpha subunit binds GM-CSF
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