Source:http://www.reactome.org/biopax/48887BiochemicalReaction2841
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Authored: Ray, KP, 2010-05-17,
Edited: Jupe, S, 2010-08-06,
Grb2 stabilizes the Shc/SHIP complex (Harmer & DeFranco 1999), presumably by simultaneously binding via its SH3 domains to SHIP and via its SH2 domain to phosphotyrosines on Shc. This forms a ternary complex of SHC1:GRB2:SHIP described as an outcome of IL-3, IL-5 or GM-CSF stimulation (Lafrancone et al. 1995, Odai et al. 1997). SHIP2 also associates with SHC1 but does not appear to require Grb2 for stability (Wisniewskiet al. 1999).,
Reviewed: Dooms, H, 2011-03-17,
Reviewed: Villarino, A, 2011-02-11
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The SHC1:SHIP1 complex is stabilized by GRB2
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