Source:http://www.reactome.org/biopax/48887BiochemicalReaction2839
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Authored: Ray, KP, 2010-05-17,
Edited: Jupe, S, 2010-08-06,
Recruitment of Sos1 to the receptor complex brings it into contact with membrane-associated Ras-GDP. Interactions with Ras modulate Sos1 activity in a two-step manner (McKay & Morrison, 2007). Sos1 acts as a guanine exchange factor for Ras (Chardin et al. 1993), activating the Ras-Raf-MAPK pathway.,
Reviewed: Dooms, H, 2011-03-17,
Reviewed: Villarino, A, 2011-02-11
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SOS1 activates H-Ras
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