Source:http://www.reactome.org/biopax/48887BiochemicalReaction2836
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Authored: Ray, KP, 2010-05-17,
Binding of Gab2 to tyrosine phosphorylated Shc promotes the phosphorylation of Gab2 by an unknown kinase. Gab2 becomes tyrosine phosphorylated in response to IL-2 (Brockdorff et al. 2001) and IL-3 (Gu et al. 1998). Chimeric receptors were used to demonstrate that Shc is sufficient for Gab2 tyrosine phosphorylation. In response to IL-3, Grb2 was also required, reflecting that Gab2 is recruited to the activated cytokine receptor complex as a complex of Gab2:Grb2 (Gu et al. 2000).,
Edited: Jupe, S, 2010-08-06,
Reviewed: Dooms, H, 2011-03-17,
Reviewed: Villarino, A, 2011-02-11
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SHC1 mediates cytokine-induced phosphorylation of GAB2
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