Source:http://www.reactome.org/biopax/48887BiochemicalReaction2820
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Authored: Ray, KP, 2010-05-17,
Edited: Jupe, S, 2010-05-17,
NFkappaB p105 protein (p105) is a precursor of the NFkappaB p50 subunit and an inhibitor of NFkappaB. The IkappaB kinase (IKK) complex phosphorylates p105 on S927 within the PEST region. TNF-alpha-induced p105 proteolysis additionally requires the phosphorylation of S932. Purified IKK (IKK1) or IKKB (IKK2) can phosphorylate both these regulatory serines in vitro.,
Reviewed: Pinteaux, E, 2010-05-17
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The IKKB complex phosphorylates NFkB p105
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2.7.11.10
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