Source:http://www.reactome.org/biopax/48887BiochemicalReaction2817
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Authored: Ray, KP, 2010-05-17,
Edited: Jupe, S, 2010-05-17,
IRAK1 and 4 can phosphorylate Pellino-1 and -2 and probably -3. Phosphorylation enhances the E3 ligase activity of Pellino-1 in conjunction with several different E2-conjugating enzymes (Ubc13-Uev1a, UbcH4, or UbcH5a/5b). Phosphorylation at any of several different sites or a combination of other sites leads to full activation of Pellino-1 E3 ubiquitin ligase activity.<br><br>Though not shown here, the current models of IRAK1 involvement suggest it is part of a complex that includes TRAF6.,
Reviewed: Pinteaux, E, 2010-05-17
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IRAK1 and 4 can phosphorylate Pellino-1 and 2.
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2.7.11
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