Source:http://www.reactome.org/biopax/48887BiochemicalReaction2816
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Authored: Ray, KP, 2010-05-17,
Edited: Jupe, S, 2010-05-17,
IRAK1 and 4 interact with Pellino-1 (Jiang et al. 2003), 2 (Strellow et al. 2003) and 3 (Butler et al. 2005, 2007). Pellinos may act as scaffolding proteins, bringing signaling complexes into proximity. They are E3 ubiquitin ligases capable of ubiquitinating IRAK1, believed to mediate IL-1-stimulated formation of K63-polyubiquitinated IRAK1 in cells.<br><br>Though not clearly demonstrated and therefore not shown here, the current models of IRAK1 involvement suggest it would be within a complex including TRAF6.,
Reviewed: Pinteaux, E, 2010-05-17
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| biopax3:xref |
http://identifiers.org/pubmed/12496252,
http://identifiers.org/pubmed/12860405,
http://identifiers.org/pubmed/15917247,
http://identifiers.org/pubmed/17675297,
http://identifiers.org/pubmed/17997719,
urn:biopax:UnificationXref:REACTOME DATABASE ID_450690,
urn:biopax:UnificationXref:REACTOME_REACT_22286_1
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IRAK1 and 4 interact with Pellino1,2 and 3
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