Source:http://www.reactome.org/biopax/48887BiochemicalReaction2811
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Authored: Ray, KP, 2010-05-17,
Edited: Jupe, S, 2010-05-17,
MyD88 and Tollip only bind to non-phosphorylated IRAK1 [Wesche et al. 1997) so hyper-phosphorylated IRAK1 is predisposed to release from the receptor complex, a key step in this signaling cascade. It is believed that the interaction of IRAK1 with TRAF6 enables the release of IRAK1:TRAF6 from the receptor (Gottipati et al. 2007). Though released from the receptor complex, IRAK1:TRAF6 remains associated with the membrane, perhaps due to subsequent interaction with the TAK1 complex (Dong et al. 2006).,
Reviewed: Pinteaux, E, 2010-05-17
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TRAF6 binding leads to IRAK1:TRAF6 release
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