Source:http://www.reactome.org/biopax/48887BiochemicalReaction2799
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Authored: Ray, KP, 2010-05-17,
Edited: Jupe, S, 2010-05-17,
Reviewed: Pinteaux, E, 2010-05-17,
The interleukin 1 receptor antagonist protein (ILRAP or IL1RN) is a member of the IL1 family that binds to IL1R1 (and with much lower affinity IL1R2) but does not elicit a signaling response. By competing with IL1 for IL1R1 binding ILRAP acts as a natural antagonist, inhibiting the biological actions of both agonist forms of IL1 (IL1 alpha and IL1 beta).
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IL1 receptor antagonist protein binds Interleukin 1 receptors
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