Source:http://www.reactome.org/biopax/48887BiochemicalReaction2787
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Authored: Garapati, P V, 2011-01-18,
Edited: Garapati, P V, 2011-01-18,
Reviewed: Zhang, DE, 2011--0-2-,
The transcription factor IRF3 is a target for ISGylation. Conjugation of ISG15 positively regulates IRF3 and thereby promotes induction of type I interferons. ISGylation of IRF3 prevents the binding of PIN1, a protein that promotes IRF3 ubiquitination and subsequent degradation.
|
| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
ISGylation of IRF3
|
| biopax3:eCNumber |
6.3.2.19
|
| biopax3:left | |
| biopax3:right |