Source:http://www.reactome.org/biopax/48887BiochemicalReaction2783
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Authored: Garapati, P V, 2011-01-18,
Edited: Garapati, P V, 2011-01-18,
Reviewed: Zhang, DE, 2011--0-2-,
Ubiquitin conjugating E2 enzymes UBC13 and UBCH6 are targets for ISGylation. This suppresses the ubiquitin-conjugating activity of both UBC13 and UBCH6. This modification may play an important role in the control of signal transduction pathways, such as the NF-kB pathway, which are associated with K63-linked polyubiquitination (Takeuchi et al, 2005).
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ISGylation of E2 conjugating enzymes
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6.3.2.19
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