Source:http://www.reactome.org/biopax/48887BiochemicalReaction2782
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Authored: Garapati, P V, 2011-01-18,
Edited: Garapati, P V, 2011-01-18,
Protein phosphatase 1 beta (PPM1B/PP2CB) is a target for ISG15. PP2CB dephosphorylates TAK1 and suppresses TAK1/TAB1-mediated IkB alpha degradation and thereby controls the NF-kB signaling pathway, which plays a critical role in innate and adaptive immunity and cancer. ISGylation of PP2CB may block the suppressive function of the phosphatase against TAK1/TAB1 mediated NF-kB activation.,
Reviewed: Zhang, DE, 2011--0-2-
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ISGylation of protein phosphatase 1 beta (PP2CB)
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6.3.2.19
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