Source:http://www.reactome.org/biopax/48887BiochemicalReaction2781
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Authored: Garapati, P V, 2011-01-18,
Edited: Garapati, P V, 2011-01-18,
ISG15 negatively regulates the scaffold protein filamin B. In response to type I IFNs, filamin B recruits RAC1, MEKK1, and MKK4, enhancing their sequential activation and thereby promoting JNK activation and apoptosis. ISGylation of filamin B leads to the disassociation of RAC1, MEKK1, and MKK4 from the scaffold, preventing type I IFN dependent JNK activation and apoptosis. It has been suggested that this inhibition of apoptosis may protect uninfected bystander cells from IFN-mediated apoptosis (Jeon et al, 2009).,
Reviewed: Zhang, DE, 2011--0-2-
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| biopax3:xref |
http://identifiers.org/pubmed/12582176,
http://identifiers.org/pubmed/16009940,
http://identifiers.org/pubmed/19270716,
http://identifiers.org/pubmed/20153823,
http://identifiers.org/pubmed/20946978,
http://www.reactome.org/biopax/48887PublicationXref5733,
urn:biopax:UnificationXref:REACTOME DATABASE ID_1169398,
urn:biopax:UnificationXref:REACTOME_REACT_115658_1
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ISGylation of host protein filamin B
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6.3.2.19
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