Source:http://www.reactome.org/biopax/48887BiochemicalReaction2779
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Authored: Garapati, P V, 2011-01-18,
Edited: Garapati, P V, 2011-01-18,
Reviewed: Zhang, DE, 2011--0-2-,
Ubiquitin ligase HERC5/CEB1 appears to be the predominant E3 ligase for ISGylation; EFP and HHARI/ARIH1 have also been reported as ISG15 E3 ligases. The E3 ligase recognizes specific target substrates and mediates the transfer of ISG15 from E2 to the substrate.
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Interaction of E3 ligase with ISG15:E2 complex
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