Source:http://www.reactome.org/biopax/48887BiochemicalReaction2777
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Authored: Garapati, P V, 2011-01-18,
Edited: Garapati, P V, 2011-01-18,
Reviewed: Zhang, DE, 2011--0-2-,
Ubiquitin ligase UBE1L is the ISG15 activating enzyme. UBE1L activates ISG15 in an ATP-dependent process that links UBE1L to ISG15 via a thioester bond. Arginine 153 (R153) in human ISG15 is identified as the key residue for ISG15 and UBE1L's interaction.
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Activation of ISG15 by UBE1L E1 ligase
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6.3.2.19
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