Source:http://www.reactome.org/biopax/48887BiochemicalReaction2775
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Authored: Garapati, P V, 2010-06-08,
Edited: Garapati, P V, 2010-07-07,
PIAS1 protein interacts directly with phoshorylated STAT1 dimers and inhibit the transcriptional activity of STAT1 by blocking the DNA-binding domain of STAT1. It has also been suggested that PIAS proteins might regulate transcription by promoting small ubiquitin-related modifier (SUMO1) conjugation of STAT1. The significance of STAT1 sumoylation in regulating STAT1 activity is controversial and needs to be clarified.,
Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17
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PIAS1 binds p-STAT1 dimer
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