Source:http://www.reactome.org/biopax/48887BiochemicalReaction2769
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Authored: Garapati, P V, 2010-06-08,
Edited: Garapati, P V, 2010-07-07,
Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17,
The phosphorylated STAT1 on IFNGR1 chains homodimerize through reciprocal SH2-phosphotyrosine interactions to form p-STAT1 homodimer called gamma-activated-factor (GAF). This phosphorylated STAT1 homodimer disassociates from the receptor complex and translocates to the nucleus.
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Release of STAT1 dimer from active receptor unit
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