Source:http://www.reactome.org/biopax/48887BiochemicalReaction2746
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Authored: Garapati, P V, 2010-07-07,
Edited: Garapati, P V, 2010-07-07,
Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17,
TYK2 functions as part of a receptor complex to trigger intracellular signaling in response to IFNA/B. TYK2 bound to IFNAR1 subunit is activated in response to IFNA/B treatment and this in turn phosphorylates two tyrosine residues Y466 and Y481 in the juxta-membrane region of IFNAR1.
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Phosphorylation of INFAR1 by TYK2
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2.7.10
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