Source:http://www.reactome.org/biopax/48887BiochemicalReaction2717
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Authored: Jupe, S, 2011-04-28,
Edited: Jupe, S, 2011-07-27,
Pre-pro-defensins are cleaved in the golgi by undefined proteases which remove the signal peptide (Yang et al. 2004, Pazgier et al. 2006). Subsequently, alpha-defensins are cleaved again to produce the biologically active mature peptide. Beta defensins have much shorter propieces and may be active once the signal peptide is removed. Further N-terminal processing of the mature defensin may yield multiple forms of the same peptide (Pazgier et al. 2006).,
Reviewed: McDermott, AM, 2011-11-03
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Pre-pro-defensins are cleaved to remove the signal peptide
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