Source:http://www.reactome.org/biopax/48887BiochemicalReaction2695
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Authored: Garapati, P V, 2010-08-02,
Edited: Garapati, P V, 2010-08-02,
Reviewed: Kawai, T, Akira, S, 2010-10-30,
TRAF family member-associated NF-kB activator (TANK also known as I-TRAF) plays an important role in IFN induction through both RIG-I and Toll-like receptor-dependent pathways. TANK has been identified as a TRAF6 binding protein. Transient transfection experiments in 293T cells revealed that TRAF6 associates with IPS-1, TBK1, IKKi, and TANK (Konno H et al).
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Recruitment of TANK to TRAF6
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