Source:http://www.reactome.org/biopax/48887BiochemicalReaction2681
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Authored: Garapati, P V, 2010-08-02,
Edited: Garapati, P V, 2010-08-02,
Reviewed: Kawai, T, Akira, S, 2010-10-30,
TRAF3 a E3 ligase for K63-linked polyubiquitination, is one of the critical molecules required for mediating IPS-1 dependent type I IFN production. TRAF3 interacts directly with IPS-1 through the TRAF domain of TRAF3 and a TRAF-interaction motif (TIM) with in IPS-1.
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Recruitment of TRAF3 to IPS-1
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