Source:http://www.reactome.org/biopax/48887BiochemicalReaction2680
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Authored: Garapati, P V, 2010-08-02,
Edited: Garapati, P V, 2010-08-02,
Reviewed: Kawai, T, Akira, S, 2010-10-30,
Upon binding the dsRNA, RIG-I and MDA5 recruit downstream signal transducer, a mitochondria-bound protein: IPS-1/VISA/MAVS/CARDIF. This mitochondria-bound adaptor has been given four different names according to the various groups who identified it: MAVS, mitochondrial antiviral signaling; IPS-1, interferonbeta promoter stimulator 1; VISA, virus-induced signaling adaptor; CARDIF, CARD adaptor inducing IFNbeta. IPS-1 is an adaptor protein with an N-terminal CARD-like domain (CLD) and with this it associates with the CARD regions of RIG-I and MDA5 and mediate the induction of interferons.
|
| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
RIG-I/MDA5 interacts with IPS-1
|
| biopax3:left | |
| biopax3:right |