Source:http://www.reactome.org/biopax/48887BiochemicalReaction2645
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Authored: Jupe, S, 2011-04-08,
Edited: Jupe, S, 2011-04-28,
Reviewed: Kufer, TA, 2011-04-28,
Reviewed: Rittinger, K, 2011-06-06,
Reviewed: Wong, Edmond, 2011-06-06,
p38 MAPK has 4 representative isoforms in humans, p38 alpha (Han et al. 1993), p38-beta (Jiang et al. 1996), p38-gamma (Lechner et al. 1996) and p38-delta (Hu et al. 1999). All are activated by phosphorylation on a canonical TxY motif by the dual-specificity kinase MKK6, which displays minimal substrate selectivity amongst the p38 isoforms (Zarubin & Han, 2005). p38 alpha and gamma are also activated by MKK3.
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| biopax3:xref |
http://identifiers.org/pubmed/10066767,
http://identifiers.org/pubmed/15686620,
http://identifiers.org/pubmed/7693711,
http://identifiers.org/pubmed/8633070,
http://identifiers.org/pubmed/8663524,
http://identifiers.org/pubmed/9430721,
urn:biopax:UnificationXref:REACTOME DATABASE ID_1247960,
urn:biopax:UnificationXref:REACTOME_REACT_75807_1
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Activation of p38 MAPK
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