Source:http://www.reactome.org/biopax/48887BiochemicalReaction2621
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Authored: Jupe, S, 2010-10-26,
Edited: Jupe, S, 2010-11-01,
Factor I cleaves the truncated alpha (a') chain of C4b between Arg-1336 and Asn-1337 and then again between Arg-956 and Thr-957, producing a 16 kDa fragment known as alpha4, derived from the C terminus of the a' chain, followed by a 27 kDa alpha3 fragment. The remaining alpha 2 (C4d) fragment stays covalently bound to the cell membrane while the complex of disulfide-linked alpha3, alpha4, beta chain and gamma chain are released (C4c) into the fluid phase (Fujita et al. 1978).,
Reviewed: Bradley, DT, 2012-02-13,
Reviewed: Fraczek, LA, 2012-02-13
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| biopax3:xref |
http://identifiers.org/pubmed/1386357,
http://identifiers.org/pubmed/3295051,
http://identifiers.org/pubmed/6214588,
http://identifiers.org/pubmed/702059,
http://identifiers.org/pubmed/7391570,
urn:biopax:UnificationXref:REACTOME DATABASE ID_977615,
urn:biopax:UnificationXref:REACTOME_REACT_118673_2
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Factor I inactivates MCP/CR1-bound C4b/C3b
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3.4.21
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