Source:http://www.reactome.org/biopax/48887BiochemicalReaction2609
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Authored: Jupe, S, 2010-10-26,
Edited: Jupe, S, 2010-11-01,
Factor H (FH) regulates the alternative pathway C3 convertase C3bBb and its C3b component both in plasma and at host cell surfaces. FH binds to membrane-associated C3b, competing with Factor B and thereby preventing formation of the active C3 convertase C3bBb. In addition, it acts as a cofactor for the Factor I-mediated proteolytic inactivation of C3b to iC3b.,
Reviewed: Bradley, DT, 2012-02-13,
Reviewed: Fraczek, LA, 2012-02-13
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Factor H binds to membrane-associated C3b
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